Saliva: An Emerging Adjunct Biomarker for Psoriasis –Trends, Scope and Relevance
9.38$
1Simranjit Singh*, 2Pratibha Ramani, 3N.D. Jayakumar, 4Sileena Jaideep Pannu, 5Ravi Kant Sharma, 6Sushil Kumar Upadhyay and 7Anil Kumar Sharma**
Bulletin of Pure and Applied Sciences
Zoology (Animal Science), Vol.42A, No.2,
July-December 2023: P.340-346
Description
Description
1Simranjit Singh*, 2Pratibha Ramani, 3N.D. Jayakumar, 4Sileena Jaideep Pannu, 5Ravi Kant Sharma, 6Sushil Kumar Upadhyay and 7Anil Kumar Sharma**
| Author’s Affiliation:
1Department of Oral Pathology, Dr. Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab University, Chandigarh, 160014, India. 2Dept of Oral Pathology, Saveetha Dental College and Hospital. SIMATS, Chennai, Tamil Nadu 600077, India. 3Dept. of Periodontics, Saveetha Dental College and Hospital. SIMATS, Chennai, Tamil Nadu 600077, India. 4Dr. Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab University, Chandigarh, 160014, India. 5Department of Biochemistry, Dr.Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab university, Chandigarh, 160014, India. 6Department of Bio-Sciences and Technology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala-133207, Haryana, India. 7Department of Biotechnology, Amity University, Sector 82 A, IT City Rd, Block D, Sahibzada Ajit Singh Nagar, Mohali, Panjab-140306, India.
|
| Corresponding author:
*Dr. Simranjit Singh, Department of Oral Pathology, Dr. Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab University, Chandigarh, 160014, India. E-mail: drsimran2907@gmail.com **Dr. Anil Kumar Sharma, Professor, Department of Biotechnology, Amity University, Sector 82 A, IT City Rd, Block D, Sahibzada Ajit Singh Nagar, Mohali, Panjab 140306, India. E-mail: anibiotech18@gmail.com. ORCID ID: AKS: https://orcid.org/0000-0002-9768-1644
|
Abstract
Psoriasis is a widely prevalent chronic immuno-inflammatory dermatological disease resulting from a complex and dynamic interplay of genetic, environmental, and immunological aetiologies. It manifests as characteristic erythematous psoriatic plaques visible to the naked eye, but prognostic biomarkers for disease monitoring and therapeutic effectiveness are still absent. Saliva is a biological fluid that, besides being critical to maintaining oral homeostasis, harbors various salivary microbiota and inflammatory markers. It can be easily collected, stored, and analyzed. Oral fluids offer an excellent advantage for biomarker study as they are non-invasive and fast techniques. Studies showed that the saliva of healthy individuals and those with psoriasis had differences in the levels of inflammatory cytokines, immunoglobulin A, and anti-oxidant biomarkers. In GCF, individuals with psoriasis showed higher levels of S100A8, IL-18, and sE-selectin than healthy individuals, independent of periodontal status. Oxidative stress(OS) is one of the pathogenetic factors of psoriasis. Thus levels of ROS and anti-oxidants can also become important factors in diagnosis.
Keywords: Psoriasis, Saliva, Biomarker
