Antidiabetic Efficacy of Citrullus colocynthis and Citrullus lanatus: A Review

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Antidiabetic Efficacy of Citrullus colocynthis and Citrullus lanatus: A Review

1Aderiike Adewumi, 2Rufus Animashaun, 3Oluwapelumi Micheal Ajiboye*, and 4Kayode Olusola Ogunwenmo

Bio-Science Research Bulletin

Volume 39, Number 1

January-June 2023: P.39-51

DOI: 10.48165/bpas.2023.39.1.6

Review Article
Description

Description

Antidiabetic Efficacy of Citrullus colocynthis and Citrullus lanatus: A Review

1Aderiike Adewumi, 2Rufus Animashaun, 3Oluwapelumi Micheal Ajiboye*, and 4Kayode Olusola Ogunwenmo

Author’s Affiliation:

1Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria

E-mail: adewumia@babcock.edu.ng

2Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria

E-mail: animashaunr@babcock.edu.n

3Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria

E-mail: oluwapelumiajii@gmail.com

4Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria

E-mail: ogunwenmok@babcock.edu.ng

 

*Corresponding Author:

Oluwapelumi Micheal Ajiboye

Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria

E-mail: oluwapelumiajii@gmail.com

 

Received on 20.01.2023

Revised on 23.03.2023

Approved on 17.05.2023

Accepted on 27.05.2023

Published on 19.06.2023

Abstract
ABSTRACT The present review is focused on the anti-diabetic potential of Citrullus colocynthis and Citrullus lanatus, commonly referred to as bitter apple and watermelon, respectively. The plants have a history of being employed for therapeutic uses and recent investigation has revealed their potential as antidiabetic agents owing to the presence of bioactive compounds, including cucurbitacins, flavonoids, and alkaloids. The present study examines the therapeutic potential of the plants, highlighting their antidiabetic, anti-inflammatory, antioxidant, and hypoglycemic properties. Additionally, the mechanisms responsible for the antidiabetic effects of these substances, and their effectiveness in the treatment of diabetes in animal and human subject. In addition to safety and toxicity, potential adverse effects were also discussed. In conclusion, these plants possess considerable potential as alternative therapies for diabetes. However, additional investigation is required to extensively comprehend their therapeutic efficacy and establish appropriate and safe dosages for clinical application.    KEYWORDS: Anti-inflammatory, Antioxidant, Hypoglycemic, Cucurbitacins, Flavonoids, Alkaloids